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HIV Infection, Antiretroviral Therapy Initiation and Longitudinal Changes in Biomarkers of Organ Function.
Conclusions: HIV infection is associated with longitudinal changes in serum levels of several biomarkers of end-organ function/disease and mortality. Multiple biomarkers (triglycerides, LDL cholesterol, hemoglobin, and FIB-4 ) remain altered from levels prior to HIV infection levels even following inititiation of ART and evidence of viral suppression. These results give insights into underlying mechanisms of increased risk for aging-related chronic diseases in the context of HIV infection. PMID: 25034208 [PubMed - in process]
Source: Current HIV Research - July 23, 2014 Category: Infectious Diseases Authors: So-Armah KA, Chang J, Alcorn C, Lo Re V, Baker JV, Tracy R, Butt AA, Agan BK, Rimland D, Gibert CL, Goetz MB, Oursler KK, Rodriguez-Barradas MC, Kuller LH, Brown ST, Stein JH, Skanderson M, Justice AC, Freiberg MS Tags: Curr HIV Res Source Type: research

Dyslipidemia and cardiovascular disease risk profiles of patients attending an HIV treatment clinic in Harare, Zimbabwe
Danai Tavonga Zhou,1,2 Vitaris Kodogo,1 Kudzai Fortunate Vongai Chokuona,1 Exnevia Gomo,1 Olav Oektedalen,3 Babill Stray-Pedersen21Department of Medical Laboratory Sciences, College of Health Sciences, University of Zimbabwe, Avondale, Zimbabwe; 2Institute of Clinical Medicine, University in Oslo, Oslo University Hospital, Oslo, Norway; 3Department of Infectious Diseases, Oslo University Hospital, Oslo, NorwayAbstract: The chronic inflammation induced by human immunodeficiency virus (HIV) contributes to increased risk of coronary heart disease (CHD) in HIV-infected individuals. HIV-infected patients generally benefit from ...
Source: HIV/AIDS - Research and Palliative Care - May 13, 2015 Category: Infectious Diseases Tags: HIV/AIDS - Research and Palliative Care Source Type: research

Association of lower adiponectin plasma levels, increased age and smoking with subclinical atherosclerosis in patients with HIV-1 infection.
CONCLUSION: Low adiponectin was associated with higher cIMT in HIV-1-infected patients on cART. Low adiponectin levels in combination with age and smoking could explain, in part, the increased subclinical atherosclerosis observed in these patients. Adiponectin may be a good candidate for predicting subclinical atherosclerosis in the management of HIV1-infected patients in public health care, especially where USGD is not available. PMID: 32516102 [PubMed - as supplied by publisher]
Source: Current HIV Research - June 8, 2020 Category: Infectious Diseases Authors: Bellinati PQ, Alfieri DF, Flauzino T, Junior PFG, Rossi DJ, Breganó JW, Simão ANC, de Almeida ERD, Lozovoy MAB, Reiche EMV Tags: Curr HIV Res Source Type: research

FGF21 and its Relationship with Inflammatory and Metabolic Parameters in HIV Patients after Antiretroviral Treatment.
CONCLUSIONS: The decrease of serum FGF21 levels due to ART is associated with the alteration in lipid profile and an increased risk for cardiovascular diseases. These variations are predictors of inflammatory status in HIV patients using antiretroviral therapy. PMID: 32684151 [PubMed - as supplied by publisher]
Source: Current HIV Research - July 18, 2020 Category: Infectious Diseases Authors: Ruiz-Padilla AJ, Ruiz-Noa Y, Del Rocio Ibarra-Reynoso L, Lazode-la-Vega-Monroy ML, Alonso-Castro AJ, Sánchez-Barajas M, Alvarez-Alvarez RM, Del Carmen Preciado-Puga M Tags: Curr HIV Res Source Type: research

Mechanisms and primary prevention of atherosclerotic cardiovascular disease among people living with HIV
Purpose of review To highlight mechanisms of elevated risk of atherosclerotic cardiovascular disease (ASCVD) among people living with HIV (PLWH), discuss therapeutic strategies, and opportunities for primary prevention. Recent findings HIV-associated ASCVD risk is likely multifactorial and due to HIV-specific factors and traditional risk factors even in the setting of treated and suppressed HIV disease. Although a growing body of evidence suggests that inflammation and immune activation are key drivers of atherogenesis, therapies designed to lower inflammation including colchicine and low-dose methotrexate have ...
Source: Current Opinion in HIV and AIDS - May 1, 2021 Category: Infectious Diseases Tags: HIV-ASSOCIATED CO-MORBIDITIES: Edited by Morris Schambelan and Todd T. Brown Source Type: research

Evaluation of Treatment Tolerability, Satisfaction and Laboratory Parameters in HIV+ Patients Switching from Ritonavir Capsule to Tablet Formulation.
Conclusion: Results of this study suggest that the newer tablet formulation of ritonavir is better tolerated and has fewer gastrointestinal side effects than the older capsule formulation. PMID: 23721228 [PubMed - as supplied by publisher]
Source: Current HIV Research - May 28, 2013 Category: Infectious Diseases Authors: Mtambo A, Harris M, Toy J, Guillemi S, Zhang W, Lima VD, Hogg R, Montaner JS, Hull M Tags: Curr HIV Res Source Type: research

Outcomes In Older Versus Younger Patients Over 96 Weeks In Hiv-1-Infected Patients Treated With Rilpivirine Or Efavirenz In Echo And Thrive.
Conclusion: Efficacy and safety outcomes were generally similar in older versus younger patients in the ECHO and THRIVE trials. PMID: 24467642 [PubMed - as supplied by publisher]
Source: Current HIV Research - January 28, 2014 Category: Infectious Diseases Authors: Ryan R, Dayaram YK, Schaible D, Coate B, Anderson D Tags: Curr HIV Res Source Type: research

Statins and Incident Diabetes in HIV-1 Patients on cART Statins and Incident Diabetes in HIV-1 Patients on cART
The use of statins was not significantly associated with an increased risk of developing incident diabetes mellitus among HIV-1 patients, a new study reports.HIV Medicine
Source: Medscape Hiv-Aids Headlines - November 2, 2016 Category: Infectious Diseases Tags: HIV/AIDS Journal Article Source Type: news

Long-Term Treatment With Raltegravir Is Associated With Lowering Triglycerides And Platelets Count In The Older Hiv+ Population: Results From The Ral-Age Study.
CONCLUSIONS: RAL-containing regimens are safe and highly effective in the older population. RAL-treatment are associated with reduction of triglycerides and platelets count in the older population. PMID: 28969567 [PubMed - as supplied by publisher]
Source: Current HIV Research - September 27, 2017 Category: Infectious Diseases Authors: Pavone P, Giustini N, Fimiani C, Paoletti F, Falciano M, Di Sora F, Mezzaroma I, Vullo V, D Ettorre G, Salotti A, Al Moghazi S Tags: Curr HIV Res Source Type: research

Are we successfully managing cardiovascular disease in people living with HIV?
Purpose of review: The aim of this study was to discuss the most recent research in the management of cardiovascular disease (CVD) in people living with HIV (PLWHIV) with a focus on screening, primary and secondary prevention. Recent findings: The cause of CVD in PLWHIV is complex and multifactorial and creates a demand for a multifaceted approach to screening and prevention. Current screening and management of CVD risk factors in PLWHIV is suboptimal, reasons for this are not clear and the data are still scarce both in the primary and secondary preventive setting. There are no optimal routine risk screening tools availab...
Source: Current Opinion in HIV and AIDS - October 7, 2017 Category: Infectious Diseases Tags: CARDIOVASCULAR DISEASE IN HIV INFECTED PERSONS: Edited by Franck Boccara and Cameron J. Holloway Source Type: research

Impact of Lopinavir/ritonavir-and Efavirenz-based Antiretroviral Therapy on the Lipid Profile of Chinese HIV/AIDS Treatment-na ïve Patients in Beijing: A Retrospective Study.
CONCLUSIONS: Both LPV/r or EFV treatment regimens impacted patients' lipid profile. Compared to EFV-based regimens, patients on LPV/r-based regimens had increased odds of dyslipidemia, such as hypercholesterolemia, hypertriglyceridemia, or high TC/HDL-C ratio; however, there was no obvious effect on LDL-C, which is more relevant to the development of cardiovascular disease. PMID: 31654514 [PubMed - as supplied by publisher]
Source: Current HIV Research - October 24, 2019 Category: Infectious Diseases Authors: Dai L, Liu A, Zhang H, Wu H, Zhang T, Su B, Shao Y, Li J, Ye J, Scott SR, D Mahajan S, A Schwartz S, Yu H, Sun L Tags: Curr HIV Res Source Type: research

Rates of Statin Therapy in HIV vs Uninfected Patients Rates of Statin Therapy in HIV vs Uninfected Patients
In what ways might statin prescribing practices differ between patients with HIV and those who are uninfected?HIV Medicine
Source: Medscape Hiv-Aids Headlines - April 15, 2020 Category: Infectious Diseases Tags: HIV/AIDS Journal Article Source Type: news

Statin-Associated Myalgia and Vitamin D Deficiency in HIV Statin-Associated Myalgia and Vitamin D Deficiency in HIV
A new study explores the connection between vitamin D deficiency and the risk for statin-related myalgia among HIV patients receiving antiretroviral therapy.AIDS
Source: Medscape Hiv-Aids Headlines - April 6, 2017 Category: Infectious Diseases Tags: HIV/AIDS Journal Article Source Type: news

Baffling Rift Between Patients With HIV and the Right Statin Baffling Rift Between Patients With HIV and the Right Statin
The Framingham score, used to evaluate risk for a cardiovascular event, is low-balling the threat in patients with HIV. And conflicting results on the success of statins is perplexing specialists.Medscape Medical News
Source: Medscape Hiv-Aids Headlines - August 13, 2019 Category: Infectious Diseases Tags: HIV/AIDS News Source Type: news